The form-factor selected for your high-performance system affects many of the systems' characteristics, including density, redundancy, and expandability.
Lost-cost 1U units (1.75 inches high) are the typical building blocks in a high performance cluster. This form factor can usually support up to 2 processors, 2 internal hard drives, 2 PCI expansion slots, and 4 memory slots - with variations, depending on the specific configuration. Because of the small amount of chassis space, however, these units usually have few redundant components.
A 2U chassis is appropriate when more components are required for each system. The increased amount of space over a 1U sized chassis means more available expansion slots and redundant components.
4U chassis allow for the ability to add a number of different components, a full range of expansion capability with redundant components. Chassis of this size also provide better airflow (cooling) due to the amount of space within.
Blade systems are often chosen when floor space is a consideration, as components can be fitted more densely into available space. Blade systems are also typically the easiest type of systems to manage, with lower maintenance costs and smaller manpower requirements due to their modular nature.